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Literature summary extracted from
- Substitution of pyridoxal 5'-phosphate in D-serine dehydratase from Escherichia coli by cofactor analogues provides information on cofactor binding and catalysis (1999), J. Biol. Chem., 274, 36935-36943.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.3.1.18 | DL-2,3-Diaminopropionic acid | - |
Escherichia coli |  |
| 4.3.1.18 | DL-O-methyl serine | - |
Escherichia coli | |
| 4.3.1.18 | glycine | - |
Escherichia coli | |
| 4.3.1.18 | Isoserine | - |
Escherichia coli | |
| 4.3.1.18 | L-2,3-diaminopropionic acid | - |
Escherichia coli | |
| 4.3.1.18 | L-alanine | - |
Escherichia coli | |
| 4.3.1.18 | L-serine | - |
Escherichia coli | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.3.1.18 | 0.35 | - |
D-serine | 25°C, pH 7.8 | Escherichia coli | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.3.1.18 | 47920 | - |
1 * 47920 | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.1.18 | D-serine | Escherichia coli | - |
pyruvate + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.3.1.18 | Escherichia coli | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.3.1.18 | purified from k12 mutant C6 | Escherichia coli |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.3.1.18 | 100 | - |
- |
Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.1.18 | D-serine | - |
Escherichia coli | pyruvate + NH3 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.3.1.18 | monomer | 1 * 47920 | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.3.1.18 | D-serine dehydratase | - |
Escherichia coli |
| 4.3.1.18 | DSD | - |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.3.1.18 | pyridoxal 5'-phosphate | 1 pyridoxal 5'-phosphate per D-serine dehydratase molecule | Escherichia coli | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.3.1.18 | 0.035 | - |
DL-2,3-Diaminopropionic acid | 25°C, pH 7.8 | Escherichia coli | |
| 4.3.1.18 | 0.09 | - |
L-2,3-diaminopropionic acid | 25°C, pH 7.8 | Escherichia coli | |
| 4.3.1.18 | 0.33 | - |
Isoserine | 25°C, pH 7.8 | Escherichia coli | |
| 4.3.1.18 | 3 | - |
L-serine | 25°C, pH 7.8 | Escherichia coli | |
| 4.3.1.18 | 4.9 | - |
glycine | 25°C, pH 7.8 | Escherichia coli | |
| 4.3.1.18 | 17 | - |
L-alanine | 25°C, pH 7.8 | Escherichia coli | |
| 4.3.1.18 | 70 | - |
DL-O-methyl serine | 25°C, pH 7.8 | Escherichia coli | |
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