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Literature summary extracted from

  • Park, J.E.; Lenter, M.C.; Zimmermann, R.N.; Garin-Chesa, P.; Old, L.J.; Rettig, W.J.
    Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts (1999), J. Biol. Chem., 274, 36505-36512.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B28
-
Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.B28 S624A inactive mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B28 diisopropylfluorophosphate 50% inhibition at 0.02 mM Homo sapiens
3.4.21.B28 phenylmethylsulfonyl fluoride 50% inhibition at 0.1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.B28 0.46
-
Ala-Pro-4-trifluoromethylcoumarin-7-amide pH 7.8, 37°C Homo sapiens
3.4.21.B28 0.9
-
Lys-Pro-4-trifluoromethylcoumarin-7-amide pH 7.8, 37°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B28 215000
-
SDS-PAGE under nonreducing conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B28 Type I collagen + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B28 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B28 fibroblast reactive tumor stromal fibroblast and granulation tissue during wound healing Homo sapiens
-
3.4.21.B28 additional information no activity in normal adult human tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B28 Ala-Pro-4-trifluoromethylcoumarin-7-amide + H2O
-
Homo sapiens Ala-Pro + 7-amino-4-trifluoromethylcoumarin
-
?
3.4.21.B28 Gelatin + H2O
-
Homo sapiens ?
-
?
3.4.21.B28 Lys-Pro-4-trifluoromethylcoumarin-7-amide + H2O
-
Homo sapiens Lys-Pro + 7-amino-4-trifluoromethylcoumarin
-
?
3.4.21.B28 Type I collagen + H2O
-
Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
3.4.21.B28 dimer
-
Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B28 FAP
-
Homo sapiens
3.4.21.B28 seprase
-
Homo sapiens