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Literature summary extracted from
- Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans (1999), J. Biol. Chem., 274, 34877-34883.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.2.1.8 | - |
Caenorhabditis elegans |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 5.2.1.8 | two crystal forms are grown, hanging-drop vapour-diffusion method, solved to a resolution of 1.8 A | Caenorhabditis elegans |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.2.1.8 | cyclosporin A | IC50: 16 nM | Caenorhabditis elegans |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.2.1.8 | additional information | Caenorhabditis elegans | class3 cyclophilins are involved in cellular responses to stress caused by changes in redox environment or by upregulation of cellular activity | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.2.1.8 | Caenorhabditis elegans | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.2.1.8 | - |
Caenorhabditis elegans |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.2.1.8 | additional information | class3 cyclophilins are involved in cellular responses to stress caused by changes in redox environment or by upregulation of cellular activity | Caenorhabditis elegans | ? | - |
? | |
| 5.2.1.8 | N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide | - |
Caenorhabditis elegans | N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.2.1.8 | cyclophilin 3 | - |
Caenorhabditis elegans |
| 5.2.1.8 | CYP-3 | - |
Caenorhabditis elegans |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 5.2.1.8 | 0.000016 | - |
IC50: 16 nM | Caenorhabditis elegans | cyclosporin A | |
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Release 2023.1 (January 2023)
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