EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B14 | isozymes SEP and SEPDELTA, DNA determination and analysis, transient expression of both isoforms in CHO cells | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B14 | 1,10-phenanthroline | inhibition of the soluble isozyme SEP | Mus musculus | |
3.4.24.B14 | additional information | no inhibition by captopril | Mus musculus | |
3.4.24.B14 | phosphoramidon | inhibition of the soluble isozyme SEP | Mus musculus | |
3.4.24.B14 | thiorphan | inhibition of the soluble isozyme SEP | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.B14 | extracellular | isozyme SEP also is secreted | Mus musculus | - |
- |
3.4.24.B14 | membrane | isozymes SEP and SEPDELTA | Mus musculus | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B14 | Zn2+ | zinc-metalloprotease | Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.24.B14 | 110000 | - |
x * 110000, membrane-bound isozymes SEP and SEPDELTA, SDS-PAGE, x * 126000, soluble isozyme SEP, SDS-PAGE | Mus musculus |
3.4.24.B14 | 126000 | - |
x * 110000, membrane-bound isozymes SEP and SEPDELTA, SDS-PAGE, x * 126000, soluble isozyme SEP, SDS-PAGE | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B14 | protein + H2O | Mus musculus | - |
peptides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B14 | Mus musculus | Q9JLI3 | 2 isozymes SEP and splicing variant SEPDELTA which lacks 69 base pair nucleotide segment following the transmembrane helix | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.24.B14 | glycoprotein | soluble isozyme SEP, and membrane-bound isozyme SEP and SEPDELTA | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.B14 | adrenal gland | isozymes SEP and SEPDELTA | Mus musculus | - |
3.4.24.B14 | brain | isozymes SEP and SEPDELTA | Mus musculus | - |
3.4.24.B14 | heart | isozymes SEP and SEPDELTA | Mus musculus | - |
3.4.24.B14 | intestine | isozymes SEP and SEPDELTA | Mus musculus | - |
3.4.24.B14 | kidney | isozymes SEP and SEPDELTA | Mus musculus | - |
3.4.24.B14 | liver | isozymes SEP and SEPDELTA | Mus musculus | - |
3.4.24.B14 | lung | isozymes SEP and SEPDELTA | Mus musculus | - |
3.4.24.B14 | additional information | in most cases isozyme SEPDELTA shows higher expression rates than isozyme SEP | Mus musculus | - |
3.4.24.B14 | ovary | isozyme SEP | Mus musculus | - |
3.4.24.B14 | testis | isozyme SEP, very low amount of isozyme SEPDELTA | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B14 | angiotensin I + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B14 | atrial natriuretic peptide + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B14 | bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B14 | endothelin-1 + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.B14 | protein + H2O | - |
Mus musculus | peptides | - |
? | |
3.4.24.B14 | protein + H2O | broad substrate specificity | Mus musculus | peptides | - |
? | |
3.4.24.B14 | Substance P + H2O | - |
Mus musculus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.24.B14 | ? | x * 110000, membrane-bound isozymes SEP and SEPDELTA, SDS-PAGE, x * 126000, soluble isozyme SEP, SDS-PAGE | Mus musculus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B14 | M13.008 | Merops-ID | Mus musculus |
3.4.24.B14 | More | may be identical with neprilysin EC 3.4.24.11 | Mus musculus |
3.4.24.B14 | SEP | - |
Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.B14 | 7.4 | - |
sharp pH-dependence | Mus musculus |