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Literature summary extracted from

  • Lucero, H.A.; Kaminer, B.
    The role of calcium on the activity of ERcalcistorin/protein-disulfide isomerase and the significance of the C-terminal and its calcium binding. A comparison with mammalian protein-disulfide isomerase (1999), J. Biol. Chem., 274, 3243-3251.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.4.1 expression in Escherichia coli Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.4.1 endoplasmic reticulum
-
 Homo sapiens 5783
-
5.3.4.1 endoplasmic reticulum
-
 Echinoidea 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.4.1 Ca2+ 1-5 mM Ca2+ augments the reactivation of reduced bovine pancreatic trypsin inhibitor Oryctolagus cuniculus
5.3.4.1 Ca2+ enzyme binds 23 mol Ca2+ at low affinity Echinoidea
5.3.4.1 Ca2+ recombinant ECaST/PDI binds 26 mol of Ca2+/mol of protein with a Kd of 2.8 mM, 1-5 mM Ca2+ augments the reactivation of rBPTI Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.4.1 58000
-
 x * 58000, recombinant ECaSt/PDI, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.3.4.1 Echinoidea
-
-
-
5.3.4.1 Homo sapiens
-
-
-
5.3.4.1 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.4.1
-
 Oryctolagus cuniculus
5.3.4.1
-
 Echinoidea
5.3.4.1 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.4.1 unfolded bovine pancreatic trypsin inhibitor
-
 Homo sapiens refolded bovine pancreatic trypsin inhibitor
-
 ?
5.3.4.1 unfolded bovine pancreatic trypsin inhibitor
-
 Oryctolagus cuniculus refolded bovine pancreatic trypsin inhibitor
-
 ?
5.3.4.1 unfolded bovine pancreatic trypsin inhibitor
-
 Echinoidea refolded bovine pancreatic trypsin inhibitor
-
 ?
5.3.4.1 unfolded insulin + reduced glutathione
-
 Homo sapiens refolded insulin + oxidized glutathione
-
 ?
5.3.4.1 unfolded rRNaSe refolding of reduced rRNaSe Homo sapiens refolded rRNase
-
 ?

Subunits

EC Number Subunits Comment Organism
5.3.4.1 ? x * 58000, recombinant ECaSt/PDI, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
5.3.4.1 ECaSt/PDI
-
 Oryctolagus cuniculus
5.3.4.1 ERcalcistorin/protein-disulfide isomerase
-
 Oryctolagus cuniculus
5.3.4.1 ERcalcistorin/protein-disulfide isomerase i.e. ECaSt/PDI Homo sapiens
5.3.4.1 ERcalcistorin/protein-disulfide isomerase i.e. ECaSt/PDI Echinoidea