Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Krysan, D.J.; Rockwell, N.C.; Fuller, R.S.
    Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides (1999), J. Biol. Chem., 274, 23229-23234.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.75 additional information Boc-RVRR-4-methylcoumarin-7-amide does not show any signs of substrate inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.75 0.0006
-
 AcRYRFKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
3.4.21.75 0.0008
-
 AcRYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
3.4.21.75 0.0009
-
 AcRARYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
3.4.21.75 0.001
-
 acetyl-norleucineYKR-7-amido-4-methylcoumarin pH 7.0, 37°C Homo sapiens
3.4.21.75 0.019
-
 Boc-RVRR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.75 Golgi apparatus trans Golgi network Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.75 additional information Homo sapiens implicated in maturation of substrates involved in development, signaling, coagulation, and pathogenesis, constitutive secretory pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.75 Homo sapiens
-
 human
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.75 Ac-AAKYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-AAKYKR
-
 ?
3.4.21.75 Ac-AARYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-AARYKR
-
 ?
3.4.21.75 Ac-KARYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-KARYKR
-
 ?
3.4.21.75 Ac-norleucine-YKR-4-methylcoumarin-7-amide
-
 Homo sapiens acetyl-norleucine-YKR + 7-amino-4-methylcoumarin
-
 ?
3.4.21.75 Ac-RA-norvaline-YKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RA-norvaline-YKR
-
 ?
3.4.21.75 Ac-RAKYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RAKYKR
-
 ?
3.4.21.75 Ac-RARYAR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RARYAR
-
 ?
3.4.21.75 Ac-RARYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RARYKR
-
 ?
3.4.21.75 Ac-RARYRR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RARYRR
-
 ?
3.4.21.75 Ac-RYKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RYRR
-
 ?
3.4.21.75 Ac-RYRFKR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Ac-RYRFKR
-
 ?
3.4.21.75 acetyl-norleucine-YKR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens acetyl-norleucine-YKR + 7-amino-4-methylcoumarin
-
 ?
3.4.21.75 AcRARYKK-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + AcRARYKK
-
 ?
3.4.21.75 Boc-RVRR-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens 7-amino-4-methylcoumarin + Boc-RVRR
-
 ?
3.4.21.75 additional information implicated in maturation of substrates involved in development, signaling, coagulation, and pathogenesis, constitutive secretory pathway Homo sapiens ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.75 21
-
 Boc-RVRR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
3.4.21.75 50
-
 acetyl-norleucine-YKR-7-amido-4-methylcoumarin pH 7.0, 37°C Homo sapiens
3.4.21.75 193
-
 AcRYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
3.4.21.75 200
-
 AcRYRFKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens
3.4.21.75 250
-
 AcRARYKR-4-methylcoumarin-7-amide pH 7.0, 37°C Homo sapiens