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Literature summary extracted from

  • Kuno, K.; Terashima, Y.; Matsushima, K.
    ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix (1999), J. Biol. Chem., 274, 18821-18826.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B11 adamts-1 gene maps to chromosome 16, region C3-C5, transient expression in COS-7 cells of FLAG-tagged wild-type and deletion mutants and mutant E386Q Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B11 E386Q oligonucleotide primer mutagenesis, mutation within the zinc binding motif, loss of zinc-binding capacity, loss of activity and capacity to complex with alpha2-macroglobulin Mus musculus
3.4.24.B11 additional information construction of soluble C-terminal deletion mutants, that are still able to form complexes with alpha2-macroglobulin Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B11 EDTA inhibition of complex formation with alpha2-macroglobulin Mus musculus
3.4.24.B11 additional information no inhibition by leupeptin, aprotinin, phenylmethylsulfonyl floride, and pepstatin Mus musculus
3.4.24.B11 Phenanthroline inhibition of complex formation with alpha2-macroglobulin Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B11 extracellular secreted protein binds to the matrix Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B11 Zn2+ metalloprotease, contains zinc binding motif HEXXHXXXXXHD in the metalloprotease domain Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B11 proteins + H2O Mus musculus enzyme is involved in the inflammatory process peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B11 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B11 proteolytic modification processing by furin endopeptidase in vivo Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B11 alpha2-macroglobulin + H2O cleavage of the bait region of alpha2-macroglobulin, complex formation with alpha2-macroglobulin is dependent on the proteolytic activity Mus musculus ?
-
 ?
3.4.24.B11 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B11 proteins + H2O enzyme is involved in the inflammatory process Mus musculus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B11 ADAMTS-1
-
 Mus musculus
3.4.24.B11 M12.222 Merops-ID Mus musculus