Literature summary extracted from

Sinniger, V.; Merton, R.E.; Fabregas, P.; Felez, J.; Longstaff, C.
Regulation of tissue plasminogen activator activity by cells. Domains responsible for binding and mechanism of stimulation (1999), J. Biol. Chem., 274, 12414-12422.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.68	plasminogen + H2O	Homo sapiens	-	plasmin + ?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.68	Homo sapiens	-	human	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.68	plasminogen + H2O	-	Homo sapiens	plasmin + ?	-	?
3.4.21.68	Val-Leu-Lys-p-nitroanilide + H2O	i.e. S-2251	Homo sapiens	p-nitroaniline + ?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.68	Tissue plasminogen activator	-	Homo sapiens

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
3.4.21.68	0.06	-	plasminogen	pH 7.4, 37°C	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)