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Literature summary extracted from

  • Mucha, A.; Cuniasse, P.; Kannan, R.; Beau, F.; Yiotakis, A.; Basset, P.; Dive, V.
    Membrane type-1 matrix metalloprotease and stromelysin-3 cleave more efficiently synthetic substrates containing unusual amino acids in their P1' positions (1998), J. Biol. Chem., 273, 2763-2768.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B3 expression of enzyme residues Phe102-Ser276 in Escherichia coli BL21(DE3) Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.B3 additional information
-
 2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamide substrate specificity with synthetic substrates Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B3 protein + H2O Mus musculus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B3 Mus musculus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.B3 additional information
-
 substrate specificity with synthetic substrates Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B3 dansyl-Ala-Ala-Ala-S-(phenylmethyl)cysteine-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Ala-Ala-Ala + S-(phenylmethyl)cysteine-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-(2S)-2-aminoheptanoyl-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Pro-Leu-Ala + (2S)-2-aminoheptanoyl-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-(2S)-2-aminooctanoyl-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Pro-Leu-Ala + (2S)-2-aminooctanoyl-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-(5-phenyl)Nva-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Pro-Leu-Ala + (5-phenyl)Nva-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-Met-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-Nle-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-Phe-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Pro-Leu-Ala + S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Pro-Leu-Ala + S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Ala-S-[(4-methoxyphenyl)methyl]Ser-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Pro-Leu-Ala + S-[(4-methoxyphenyl)methyl]Ser-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 dansyl-Pro-Leu-Phe-S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2 + H2O
-
 Mus musculus dansyl-Pro-Leu-Phe + S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2
-
 ?
3.4.24.B3 protein + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B3 protein + H2O substrate specificity Mus musculus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B3 M10.007 Merops-ID Mus musculus
3.4.24.B3 matrix metalloproteinase-11
-
 Mus musculus
3.4.24.B3 MMP-11
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B3 25
-
 assay at Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.24.B3 additional information
-
 additional information substrate specificity with synthetic substrates Mus musculus
3.4.24.B3 additional information
-
 2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamide substrate specificity with synthetic substrates Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.B3 7.5
-
 assay at Mus musculus