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Literature summary extracted from

  • Maehama, T.; Dixon, J.E.
    The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate (1998), J. Biol. Chem., 273, 13375-13378.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.67 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.67 C124S complete loss of activity towards inositol 1,3,4,5-tetrakisphosphate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.67 0.0989
-
 Inositol 1,3,4,5-tetrakisphosphate
-
 Homo sapiens
3.1.3.67 25.6
-
 4-nitrophenyl phosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.67 Phosphatidylinositol-3,4,5-trisphosphate + H2O Homo sapiens it is possible that the enzyme acts in vivo as a phosphoinositide 3-phosphatase by regulating phosphatidylinositol-3,4,5-trisphosphate levels Phosphatidyl inositol-4,5-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.67 293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.67 4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
3.1.3.67 inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens inositol 1,4,5-trisphosphate + phosphate
-
 ?
3.1.3.67 phosphatidylinositol 3-phosphate + H2O at 20% of the activity with phosphatidylinositol-3,4,5-trisphosphate Homo sapiens phosphatidylinositol + phosphate
-
 ?
3.1.3.67 Phosphatidylinositol-3,4,5-trisphosphate + H2O
-
 Homo sapiens Phosphatidyl inositol-4,5-bisphosphate + phosphate
-
 ?
3.1.3.67 Phosphatidylinositol-3,4,5-trisphosphate + H2O it is possible that the enzyme acts in vivo as a phosphoinositide 3-phosphatase by regulating phosphatidylinositol-3,4,5-trisphosphate levels Homo sapiens Phosphatidyl inositol-4,5-bisphosphate + phosphate
-
 ?
3.1.3.67 phosphatidylinostitol 3,4-bisphosphate + H2O at 20% of the activity with phosphatidylinositol-3,4,5-trisphosphate Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.67 PTEN/MMAC1
-
 Homo sapiens