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Literature summary extracted from

  • Manes, S.; Mira, E.; Barbacid, M.M.; Cipres, A.; Fernandez-Resa, P.; Buesa, J.M.; Merida, I.; Aracil, M.; Marquez, G.; Martinez, A.C.
    Identification of insulin-like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3 (1997), J. Biol. Chem., 272, 25706-25712.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B3 expression in MCF-7 breat adenocarcinoma cells, secretion of the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B3 matrix metalloproteinase inhibitor BB-94
-
Homo sapiens
3.4.24.B3 matrix metalloproteinase inhibitor TIMP-2
-
Homo sapiens
3.4.24.B3 additional information no inhibition by aprotinin Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.B3 60000
-
x * 60000, procesed enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B3 protein + H2O Homo sapiens enzyme plays a role in tumor progression and wound healing peptides
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B3 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B3 proteolytic modification autoproteiolytic processing Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B3 insulin-like growth factor-binding protein-1 + H2O specific for, cleavage site is the His140-Val141 bond Homo sapiens 2 peptides of 16 and 9 kDa MW
-
?
3.4.24.B3 additional information no activity with casein or gelatin Homo sapiens ?
-
?
3.4.24.B3 protein + H2O
-
Homo sapiens peptides
-
?
3.4.24.B3 protein + H2O enzyme plays a role in tumor progression and wound healing Homo sapiens peptides
-
?

Subunits

EC Number Subunits Comment Organism
3.4.24.B3 ? x * 60000, procesed enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B3 M10.007 Merops-ID Homo sapiens
3.4.24.B3 matrix metalloproteinase-11
-
Homo sapiens
3.4.24.B3 MMP-11
-
Homo sapiens
3.4.24.B3 ST-3
-
Homo sapiens