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Literature summary extracted from

  • Kazama, Y.; Hamamoto, T.; Foster, D.C.; Kisiel, W.
    Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation (1995), J. Biol. Chem., 270, 66-72.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.106 fusion protein with maltose-binding protein Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.106 4-amidinophenylmethylsulfonyl fluoride complete inhibition at 1 mM Homo sapiens
3.4.21.106 antithrombin III 76% inhibition at 0.003 mM, 1U/ml heparin enhances inhibition Homo sapiens
3.4.21.106 Aprotinin 90% inhibition at 0.008 mM Homo sapiens
3.4.21.106 additional information no inhibition by soybean trypsin inhibitor and tissue factor pathway inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.106 membrane
-
Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.106 Ca2+ optimal concentration: 5 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.106 Protein + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.106 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.106 factor X + H2O activates factor X in the presence of factor VII Homo sapiens ?
-
?
3.4.21.106 additional information enzyme does not cleave factor VII R152E mutant Homo sapiens ?
-
?
3.4.21.106 Protein + H2O
-
Homo sapiens ?
-
?
3.4.21.106 zymogen factor VII + H2O cleaves between Arg152 and Ile153 Homo sapiens factor VIIa
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.106 7 8
-
Homo sapiens