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Literature summary extracted from

  • Peng, S.B.; Wang, L.; Moomaw, J.; Peery, R.B.; Sun, P.M.; Johnson, R.B.; Lu, J.; Treadway, P
    Skatrud, P.L.; Wang, Q.M.: Biochemical characterization of signal peptidase I from gram-positive Streptococcus pneumoniae (2001), J. Bacteriol., 183, 621-627.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.89 Phospholipids stimulates enzymatic activity Streptococcus pneumoniae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.89
-
 Streptococcus pneumoniae

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.89 K76A signal peptidase I, site-directed mutagenesis Streptococcus pneumoniae
3.4.21.89 S38A signal peptidase I, site-directed mutagenesis Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.89 signal peptides from preproteins + H2O Streptococcus pneumoniae
-
 mature proteins
-
 ?
3.4.21.89 streptokinase precursor + H2O Streptococcus pneumoniae extracellular protein, produced in pathogenic streptococci streptokinase
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.89 Streptococcus pneumoniae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.89 recombinant protein Streptococcus pneumoniae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.89 additional information precursor of beta-lactamase and pre-OmpA fusion protein are no substrates, incubation at 37°C results in self-cleavage and appearance of 2 products with molecular masses of 19 kDa and 8 kDa Streptococcus pneumoniae ?
-
 ?
3.4.21.89 signal peptides from preproteins + H2O
-
 Streptococcus pneumoniae mature proteins
-
 ?
3.4.21.89 streptokinase precursor + H2O extracellular protein, produced in pathogenic streptococci Streptococcus pneumoniae streptokinase
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.21.89 37
-
 incubation at 37°C results in self-cleavage and appearance of 2 products with molecular masses of 19 kDa and 8 kDa, signal peptidase I basically loses its activity after self-cleavage Streptococcus pneumoniae