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Literature summary extracted from

  • Kimura, Y.; Miyake, R.; Tokumasu, Y.; Sato, M.
    Molecular cloning and characterization of two genes for the biotin carboxylase and carboxyltransferase subunits of acetyl coenzyme A carboxylase in Myxococcus xanthus (2000), J. Bacteriol., 182, 5462-5469.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.4.14 accA gene, sequencing, expression in Escherichia coli, forms together with accB a two-gene operon Myxococcus xanthus
6.4.1.2 carboxyltransferase and biotin carboxylase subunit, expressed in Escherichia coli Myxococcus xanthus

Protein Variants

EC Number Protein Variants Comment Organism
6.3.4.14 additional information accA disruption mutant with a reduced growth rate and reduced acetyl-CoA carboxylase activity Myxococcus xanthus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.4.14 61500
-
 x * 61500, sequence calculation, x * 65000, SDS-PAGE Myxococcus xanthus
6.3.4.14 65000
-
 x * 61500, sequence calculation, x * 65000, SDS-PAGE Myxococcus xanthus
6.4.1.2 58100
-
 carboxyltransferase subunit, calculated from amino acid sequence Myxococcus xanthus
6.4.1.2 61500
-
 biotin carboxylase subunit, calculated from amino acid sequence Myxococcus xanthus
6.4.1.2 65000
-
 biotin carboxylase subunit, SDS-PAGE Myxococcus xanthus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.14 additional information Myxococcus xanthus AccA is a biotinylated protein mainly expressed in the exponential growth phase ?
-
 ?
6.3.4.14 additional information Myxococcus xanthus IFO13542 / ATCC 25232 AccA is a biotinylated protein mainly expressed in the exponential growth phase ?
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Myxococcus xanthus key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.14 Myxococcus xanthus Q9FAF5 strain IFO13542/ATCC25232
-
6.3.4.14 Myxococcus xanthus IFO13542 / ATCC 25232 Q9FAF5 strain IFO13542/ATCC25232
-
6.4.1.2 Myxococcus xanthus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.14 ATP + biotin-carboxyl-carrier protein + HCO3- biotin carboxylase subunit AccA of acetyl-CoA carboxylase Myxococcus xanthus ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
 ?
6.3.4.14 ATP + biotin-carboxyl-carrier protein + HCO3- biotin carboxylase subunit AccA of acetyl-CoA carboxylase Myxococcus xanthus IFO13542 / ATCC 25232 ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
 ?
6.3.4.14 additional information AccA is a biotinylated protein mainly expressed in the exponential growth phase Myxococcus xanthus ?
-
 ?
6.3.4.14 additional information AccA is a biotinylated protein mainly expressed in the exponential growth phase Myxococcus xanthus IFO13542 / ATCC 25232 ?
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Myxococcus xanthus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Myxococcus xanthus ADP + phosphate + malonyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.14 ? x * 61500, sequence calculation, x * 65000, SDS-PAGE Myxococcus xanthus
6.4.1.2 multimer
-
 Myxococcus xanthus

Synonyms

EC Number Synonyms Comment Organism
6.3.4.14 AccA Myxococcus xanthus Myxococcus xanthus

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 biotin enzyme-bound Myxococcus xanthus