Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Koul, A.; Choidas, A.; Treder, M.; Tyagi, A.K.; Drlica, K.; Singh, Y.; Ullrich, A.
    Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis (2000), J. Bacteriol., 182, 5425-5432.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.48 C11S MPtpA catalytic site, no enzymic activity Mycobacterium tuberculosis
3.1.3.48 C160S MPtpB catalytic site, no enzymic activity Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 additional information not inhibitory: okadaic acid Mycobacterium tuberculosis
3.1.3.48 sodium orthovanadate
-
 Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.48 17500
-
 x * 17500, MPtpA, x * 30000, MPtpB, deduced from gene sequence Mycobacterium tuberculosis
3.1.3.48 30000
-
 x * 17500, MPtpA, x * 30000, MPtpB, deduced from gene sequence Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Mycobacterium tuberculosis
-
 isozymes MPtpA, MPtpB
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.48 glutathione S-transferase fusion proteins Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 additional information both isozymes act only on phosphotyrosine residues Mycobacterium tuberculosis ?
-
 ?
3.1.3.48 tyrosine-phosphorylated myelin basic protein + H2O
-
 Mycobacterium tuberculosis myelin basic protein + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.48 ? x * 17500, MPtpA, x * 30000, MPtpB, deduced from gene sequence Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 MPtpA
-
 Mycobacterium tuberculosis
3.1.3.48 MPtpB
-
 Mycobacterium tuberculosis