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Literature summary extracted from
- Prephenate dehydratase from the aphid endosymbiont (Buchnera) displays changes in the regulatory domain that suggest its desensitization to inhibition by phenylalanine (2000), J. Bacteriol., 182, 2967-2969.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.1.51 | DNA sequence determination and analysis of the two-domain aroQ/pheA gene, constitutive expression due to the absence of an attenuator region, changes in the ESRP sequence leading to desensitization to inhibition by phenylalanine | Buchnera aphidicola |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.51 | additional information | changes in the ESRP sequence, involved in allosteric binding of phenylalanine, lead to desensitization to inhibition by phenylalanine, permitting the overproduction of the amino aid in vivo | Buchnera aphidicola |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.51 | prephenate | Buchnera aphidicola | involved in vivo production of high levels of phenylalanine | phenylpyruvate + H2O + CO2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.51 | Buchnera aphidicola | P57472 | endosymbiont isolated from aphid Acyrthosiphon pisum | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.2.1.51 | prephenate = phenylpyruvate + H2O + CO2 | this enzyme in the enteric bacteria also possesses chorismate mutase activity, EC 5.4.99.5, and converts chorismate into prephenate | Buchnera aphidicola |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.51 | prephenate | - |
Buchnera aphidicola | phenylpyruvate + H2O + CO2 | - |
? | |
| 4.2.1.51 | prephenate | involved in vivo production of high levels of phenylalanine | Buchnera aphidicola | phenylpyruvate + H2O + CO2 | - |
? | |
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Release 2023.1 (January 2023)
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