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Literature summary extracted from

  • Kolmar, H.; Waller, P.R.; Sauer, R.T.
    The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation (1996), J. Bacteriol., 178, 5925-5929.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B50 periplasm
-
 Escherichia coli
-
-
3.4.21.107 periplasm
-
 Escherichia coli
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B50 50000
-
 6 * 50000, SDS-PAGE Escherichia coli
3.4.21.B50 50000
-
 12 * 50000, SDS-PAGE Escherichia coli
3.4.21.B50 300000
-
 hexamer, gel filtration Escherichia coli
3.4.21.B50 600000
-
 dodecamer, gel filtration Escherichia coli
3.4.21.107 50000
-
 12 * 50000, SDS-PAGE, enzyme can exist in two oligomeric forms which are interconvertible Escherichia coli
3.4.21.107 50000
-
 6 * 50000, SDS-PAGE, enzyme can exist in two oligomeric forms which are interconvertible Escherichia coli
3.4.21.107 300000
-
 gel filtration, hexameric form Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B50 additional information Escherichia coli DegQ may degrade transiently denatured proteins, unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions, and/or newly secreted proteins prior to folding and disulfide bond formation ?
-
 ?
3.4.21.107 additional information Escherichia coli involved in the degradation of denatured and unfolded proteins ?
-
 ?
3.4.21.107 Protein + H2O Escherichia coli
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B50 Escherichia coli
-
-
-
3.4.21.107 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B50
-
 Escherichia coli
3.4.21.107
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B50 Arc-st11 repressor + H2O cleavage sites: Val22-/-Arg23, Val25-/-Ala25 and Val41-/-Met42 Escherichia coli ?
-
 ?
3.4.21.B50 lambda-repressor variant 105 + H2O cleavage sites: Val36-/-Ala37, Val71-/-Ser72, Ile84-/-Tyr85, Val91-/-Ser92 Escherichia coli ?
-
 ?
3.4.21.B50 additional information DegQ may degrade transiently denatured proteins, unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions, and/or newly secreted proteins prior to folding and disulfide bond formation Escherichia coli ?
-
 ?
3.4.21.B50 additional information model substrates are cleaved at discrete Val/Xaa or Ile/Xaa sites Escherichia coli ?
-
 ?
3.4.21.107 additional information involved in the degradation of denatured and unfolded proteins Escherichia coli ?
-
 ?
3.4.21.107 Protein + H2O cleaves model substrates at discrete Val/Xaa or Ile/Xaa sites Escherichia coli ?
-
 ?
3.4.21.107 Protein + H2O
-
 Escherichia coli ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.B50 dodecamer 12 * 50000, SDS-PAGE Escherichia coli
3.4.21.B50 hexamer 6 * 50000, SDS-PAGE Escherichia coli
3.4.21.107 dodecamer 12 * 50000, SDS-PAGE, enzyme can exist in two oligomeric forms which are interconvertible Escherichia coli
3.4.21.107 hexamer 6 * 50000, SDS-PAGE, enzyme can exist in two oligomeric forms which are interconvertible Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
3.4.21.107 DegP
-
 Escherichia coli
3.4.21.107 S01.273 Merops ID Escherichia coli