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Literature summary extracted from

  • Quinto, B.M.; Juliano, M.A.; Hirata, I.; Carmona, A.K.; Juliano, L.; Casarini, D.E.
    Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates (2000), Int. J. Biochem. Cell Biol., 32, 1161-1172.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 2-mercaptoethanol
-
 Homo sapiens
3.4.21.26 benzyloxycarbonyl-Pro-prolinal
-
 Homo sapiens
3.4.21.26 Co2+
-
 Homo sapiens
3.4.21.26 dithiothreitol
-
 Homo sapiens
3.4.21.26 EDTA
-
 Homo sapiens
3.4.21.26 Hg2+
-
 Homo sapiens
3.4.21.26 additional information resistant to: PMSF, thyorphan, E64 and phosphoramidon Homo sapiens
3.4.21.26 o-phenanthroline
-
 Homo sapiens
3.4.21.26 p-hydroxymercuribenzoate
-
 Homo sapiens
3.4.21.26 PCMB
-
 Homo sapiens
3.4.21.26 Zn2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.26 0.00065
-
 2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) pH 8.0, 37°C Homo sapiens
3.4.21.26 0.00074
-
 2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) pH 8.0, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.26
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 urine
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.26 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 2-aminobenzoyl-FFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.26 2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Homo sapiens 2-aminobenzoyl-FP + Q-(N-(2,4-dinitrophenyl)ethylenediamine)
-
 ?
3.4.21.26 2-aminobenzoyl-FSQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.26 2-aminobenzoyl-RPPGFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.26 2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Homo sapiens 2-aminobenzoyl-RPP + GFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
 ?
3.4.21.26 2-aminobenzoyl-SPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.26 Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O as active as potentiator B Homo sapiens Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
-
 ?
3.4.21.26 Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O as active as potentiator B Homo sapiens Met-Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
-
 ?
3.4.21.26 additional information no activity with Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr and pGly-His-Trp-Ser-tyr-Gly-leu-Arg-Pro-Gly-NH2 Homo sapiens ?
-
 ?
3.4.21.26 pGlu-Gly-Leu-Pro-Pro-Arg-Pro + H2O i.e. potentiator B Homo sapiens pGlu-Gly-Leu-Pro-Pro + Arg-Pro
-
 ?
3.4.21.26 pGlu-Gly-Leu-Pro-Pro-Gly-Pro + H2O i.e. potentiator C, as active as potentiator B Homo sapiens pGlu-Gly-Leu-Pro-Pro + Gly-Pro
-
 ?
3.4.21.26 RPPGFSPFR + H2O i.e. bradykinin, 90% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro Homo sapiens ?
-
 ?
3.4.21.26 RPPGFSPFR-amide + H2O i.e. bradykinin, 70% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro Homo sapiens RPP + GFSPFR-amide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 PE
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.26 6.5
-
 reaction with 2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine), and a second lower optimum at pH 8.0 Homo sapiens
3.4.21.26 8
-
 reaction with bradykinin. And a second higher optimum at pH 6.5, reaction with 2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) Homo sapiens
3.4.21.26 9
-
 reaction with 2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.26 7 9 pH 7.0: about 55% of maximal activity, pH 9.0: about 30% of maximal activity, reaction with bradykinin Homo sapiens
3.4.21.26 8.5 10 pH 8.5: about 40% of maximal activity, pH 10.0: about 80% of maximal activity, reaction with 2-aminobenzoyl-BKQRPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) Homo sapiens