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Literature summary extracted from

  • Smith, M.A.; Mendz, G.L.; Jorgensen, M.A.; Hazell, S.L.
    Fumarate metabolism and the microaerophily of Campylobacter species (1999), Int. J. Biochem. Cell Biol., 31, 961-975.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.2 Cl- activity increases up to 50 mM and remains constant at higher concentrations Campylobacter jejuni

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.2 potassium thiocyanate IC50: 140 mM Campylobacter jejuni

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.2 8.8
-
 fumarate pH 7.4, 37°C Campylobacter jejuni
4.2.1.2 32
-
 (S)-malate pH 7.4, 37°C Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.2 fumarate + H2O Campylobacter jejuni constitutive enzyme L-malate
-
 ?
4.2.1.2 fumarate + H2O Campylobacter coli constitutive enzyme L-malate
-
 ?
4.2.1.2 fumarate + H2O Campylobacter fetus constitutive enzyme L-malate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.2 Campylobacter coli
-
 isolate RMIT 32A
-
4.2.1.2 Campylobacter coli
-
 strain ATCC 33559
-
4.2.1.2 Campylobacter fetus
-
 subsp. fetus ATCC 33246 and subsp. venerealis strain ATCC 19438
-
4.2.1.2 Campylobacter jejuni
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.2 (S)-malate
-
 Campylobacter jejuni fumarate + H2O
-
 r
4.2.1.2 fumarate + H2O
-
 Campylobacter jejuni L-malate
-
 ?
4.2.1.2 fumarate + H2O
-
 Campylobacter coli L-malate
-
 ?
4.2.1.2 fumarate + H2O
-
 Campylobacter fetus L-malate
-
 ?
4.2.1.2 fumarate + H2O constitutive enzyme Campylobacter jejuni L-malate
-
 ?
4.2.1.2 fumarate + H2O constitutive enzyme Campylobacter coli L-malate
-
 ?
4.2.1.2 fumarate + H2O constitutive enzyme Campylobacter fetus L-malate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.2 Fum
-
 Campylobacter jejuni
4.2.1.2 Fum
-
 Campylobacter coli
4.2.1.2 Fum
-
 Campylobacter fetus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.2 6.7
-
-
 Campylobacter jejuni

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.1.2 140
-
 IC50: 140 mM Campylobacter jejuni potassium thiocyanate