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Literature summary extracted from

  • Van Dijck, P.; De Rop, L.; Szlufcik, K.; Van Ael, E.; Thevelein, J.M.
    Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation (2002), Infect. Immun., 70, 1772-1782.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.3.12 medicine enzyme may serve as a potential target for antifungal drugs Candida albicans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.12 commentary Saccharomyces cerevisiae
3.1.3.12 construction of homozygous and heterozygous deletion mutants, the homozygous deletion mutants has little or no enzyme activity, the complete inactivation of enzyme results in 50fold hyperaccumulation of trehalose 6-phosphate, thermosensitivity, and rapid death of the cells after a few hours at 44°C Candida albicans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.12 973000
-
 calculated from amino acid sequence Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.12 trehalose 6-phosphate + H2O Candida albicans
-
 trehalose + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.12 Candida albicans
-
-
-
3.1.3.12 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.12 additional information
-
-
 Candida albicans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.12 trehalose 6-phosphate + H2O
-
 Candida albicans trehalose + phosphate
-
 ?