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Literature summary extracted from
- Diversity of calcium action in regulation of mammalian calmodulin-dependent cyclic nucleotide phosphodiesterase (2003), Indian J. Biochem. Biophys., 40, 77-91.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.17 | Calmodulin | differential effect on isozymes, activation only in complex with Ca2+, overview | Mammalia |  |
| 3.1.4.17 | Calmodulin | differential effect on isozymes, activation only in complex with Ca2+, overview | Bos taurus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.17 | 3-isobutyl-1-methylxanthine | marked differences in inhibition for isozymes | Bos taurus | |
| 3.1.4.17 | amantadine | brain 60 kDa isozyme | Bos taurus | |
| 3.1.4.17 | angiotensin III | - |
Bos taurus | |
| 3.1.4.17 | felodipine | - |
Bos taurus | |
| 3.1.4.17 | nicardipine | - |
Bos taurus | |
| 3.1.4.17 | sarilesin | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.17 | 0.0012 | - |
cGMP | brain 63 kDA isozyme | Bos taurus | |
| 3.1.4.17 | 0.0027 | - |
cGMP | brain 60 kDA isozyme | Bos taurus | |
| 3.1.4.17 | 0.0028 | - |
cGMP | lung isozyme | Bos taurus | |
| 3.1.4.17 | 0.0032 | - |
cGMP | heart isozyme | Bos taurus | |
| 3.1.4.17 | 0.012 | - |
cAMP | brain 63 kDA isozyme | Bos taurus | |
| 3.1.4.17 | 0.035 | - |
cAMP | brain 60 kDA isozyme | Bos taurus | |
| 3.1.4.17 | 0.04 | - |
cAMP | heart isozyme | Bos taurus | |
| 3.1.4.17 | 0.042 | - |
cAMP | lung isozyme | Bos taurus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.17 | cytosol | mainly | Mammalia | 5829 | - |
| 3.1.4.17 | cytosol | mainly | Bos taurus | 5829 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.17 | Ca2+ | differential effect on isozymes, activation only in complex with calimodulin, overeview | Mammalia | |
| 3.1.4.17 | Ca2+ | differential effect on isozymes, activation only in complex with calimodulin, overeview | Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.17 | additional information | - |
overview | Mammalia |
| 3.1.4.17 | 60000 | - |
2 * 60000, SDS-PAGE, brain PDE1 isoform | Bos taurus |
| 3.1.4.17 | 116000 | 124000 | sedimentation data | Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.17 | additional information | Mammalia | overview on physiological role | ? | - |
? | |
| 3.1.4.17 | additional information | Bos taurus | overview on physiological role | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.17 | Bos taurus | - |
- |
- |
| 3.1.4.17 | Mammalia | - |
overview on PDE1 isozymes | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.4.17 | phosphoprotein | 60 kDa PDE1, substrate of cAMP-dependent protein kinase, 63 kDa PDE1, substrate of calmodulin-dependent protein kinase, reversion for both by calcineurin, overview on regulation by phosphorylation | Mammalia |
| 3.1.4.17 | phosphoprotein | regulation by phosphorylation, overview | Bos taurus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.17 | overview | Mammalia |
| 3.1.4.17 | overview | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.17 | brain | highest enzymic activity | Bos taurus | - |
| 3.1.4.17 | heart | 10-20% of activity found in brain | Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.17 | additional information | - |
kinetic properties, overview | Mammalia |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.17 | cAMP + H2O | - |
Bos taurus | AMP | - |
? | |
| 3.1.4.17 | cGMP + H2O | - |
Bos taurus | GMP | - |
? | |
| 3.1.4.17 | additional information | overview on physiological role | Mammalia | ? | - |
? | |
| 3.1.4.17 | additional information | overview on physiological role | Bos taurus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.4.17 | dimer | 2 * 60000, SDS-PAGE, brain PDE1 isoform | Bos taurus |
| 3.1.4.17 | More | overview on subunit composition and partial amino acid sequences | Mammalia |
| 3.1.4.17 | More | PDE1 exists as tissue-specific and immunological distinct isozymes, overview | Bos taurus |
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Release 2023.1 (January 2023)
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