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Literature summary extracted from

  • Poppe, L.; Hull, W.E.; Nitsche, R.; Graf, T.; Stupperich, E.; Retey, J.
    (Hydroxyalkyl)cob(III)alamins as competitive inhibitors in coenzyme B12-dependent enzymic reactions. 1H-NMR structure analysis and kinetic studies with glycerol dehydratase and diol dehydratase (1999), Helv. Chim. Acta, 82, 1250-1265.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.30 (2,3-dihydroxypropyl)cobalamin competes with coenzyme B12 Klebsiella pneumoniae
4.2.1.30 Cobeta-2,3-dihydroxypropyl-[1'-O-(4-tolyl)cobamide] moderate inhibitor Klebsiella pneumoniae
4.2.1.30 HO-(CH2)n-cobalamin chain lengths of n=2-5, short chains are more effective Klebsiella pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.30 Klebsiella pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.30 glycerol
-
 Klebsiella pneumoniae 3-hydroxypropanal + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.30 coenzyme B12
-
 Klebsiella pneumoniae