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Literature summary extracted from
- Identification and characterisation of human aldose 1-epimerase (2003), FEBS Lett., 543, 21-24.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.1.3.3 | expression in Escherichia coli | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.1.3.3 | E307A | mutant enzyme without aldose 1-epimerase activity | Homo sapiens |
| 5.1.3.3 | H107A | mutant enzyme with 5fold reduced activity with alpha-D-galactose and 7.8fold reduced activity with alpha-D-glucose, compared to wild-type enzyme | Homo sapiens |
| 5.1.3.3 | H176A | mutant enzyme without aldose 1-epimerase activity | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.3.3 | 37 | - |
alpha-D-galactose | pH 8.0, 20°C | Homo sapiens |  |
| 5.1.3.3 | 54 | - |
alpha-D-glucose | pH 8.0, 20°C | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.1.3.3 | 32000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.3.3 | additional information | Homo sapiens | key enzyme of carbohydrate metabolism catalysing the interconversion of the alpha-anomer and beta-anomer of hexose sugars such as glucose and galactose | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.3.3 | Homo sapiens | Q96C23 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.1.3.3 | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.3.3 | alpha-D-galactose | - |
Homo sapiens | beta-D-galactose | - |
r | |
| 5.1.3.3 | alpha-D-glucose | - |
Homo sapiens | beta-D-glucose | - |
r | |
| 5.1.3.3 | additional information | key enzyme of carbohydrate metabolism catalysing the interconversion of the alpha-anomer and beta-anomer of hexose sugars such as glucose and galactose | Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.3.3 | 4900 | - |
alpha-D-glucose | pH 8.0, 20°C | Homo sapiens | |
| 5.1.3.3 | 12000 | - |
alpha-D-galactose | pH 8.0, 20°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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