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Literature summary extracted from
- Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP) (2000), FEBS Lett., 478, 52-56.
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B6 | Zn2+ | dependent on | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B6 | aggrecan + H2O | Homo sapiens | cleavage site is Asn341-Phe342 | ? | - |
? | |
| 3.4.24.B6 | cartilage oligomeric matrix protein + H2O | Homo sapiens | 100 kDa protein substrate | 60 kDa protein | - |
? | |
| 3.4.24.B6 | additional information | Homo sapiens | degradation of various components of the extracellular matrix during tooth development and pathological conditions | ? | - |
? | |
| 3.4.24.B6 | proteins + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.B6 | Homo sapiens | O60882 | recombinant enzyme | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.B6 | tooth | - |
Homo sapiens | - |
| 3.4.24.B6 | tooth enamel | restricted expression | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B6 | aggrecan + H2O | cleavage site is Asn341-Phe342 | Homo sapiens | ? | - |
? | |
| 3.4.24.B6 | cartilage oligomeric matrix protein + H2O | 100 kDa protein substrate | Homo sapiens | 60 kDa protein | - |
? | |
| 3.4.24.B6 | additional information | degradation of various components of the extracellular matrix during tooth development and pathological conditions | Homo sapiens | ? | - |
? | |
| 3.4.24.B6 | proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.B6 | enamel metalloproteinase | - |
Homo sapiens |
| 3.4.24.B6 | enamelysin | - |
Homo sapiens |
| 3.4.24.B6 | M10.019 | Merops-ID | Homo sapiens |
| 3.4.24.B6 | MMP-20 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.B6 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.B6 | 7.6 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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