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Literature summary extracted from
- Isolation of acein-2, a novel angiotensin-I-converting enzyme inhibitory peptide derived from a tryptic hydrolysate of human plasma (2000), FEBS Lett., 467, 235-238.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | medicine | acein-2 as well as acein-1 can be used as a starting material for anti-hypertensive drugs against ACE | Oryctolagus cuniculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Leu-Ile-Tyr | i.e. acein-2, isolated from tryptic hydrolysate of human plasma, non-competitive inhibitor, IC50: 0.00082 mM. | Oryctolagus cuniculus |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | lung | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Oryctolagus cuniculus | hippuric acid + His-Leu | - |
? | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.00082 | - |
i.e. acein-2, isolated from tryptic hydrolysate of human plasma, non-competitive inhibitor, IC50: 0.00082 mM. | Oryctolagus cuniculus | Leu-Ile-Tyr | |
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Release 2023.1 (January 2023)
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