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Literature summary extracted from

  • Wilharm, E.; Tschopp, J.; Jenne, D.E.
    Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice (1999), FEBS Lett., 459, 139-142.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B4
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B4 4-aminobenzamidine 81% inactivation at 5 mM Homo sapiens
3.4.21.B4 4-aminobenzamidine 57% inactivation at 5 mM Mus musculus
3.4.21.B4 Aprotinin 94% inactivation at 0.005 mM Homo sapiens
3.4.21.B4 Aprotinin 89% inactivation at 0.005 mM Mus musculus
3.4.21.B4 benzamidine 55% inactivation at 27 mM Homo sapiens
3.4.21.B4 benzamidine 57% inactivation at 27 mM Mus musculus
3.4.21.B4 bikunin light chain of inter-alpha-trypsin inhibitor Homo sapiens
3.4.21.B4 bikunin light chain of inter-alpha-trypsin inhibitor Mus musculus
3.4.21.B4 Glu-Gly-Arg-chloromethyl ketone 97% inactivation at 0.1 mM Homo sapiens
3.4.21.B4 Glu-Gly-Arg-chloromethyl ketone 52% inactivation at 0.1 mM Mus musculus
3.4.21.B4 leupeptin 92% inactivation at 0.2 mM Homo sapiens
3.4.21.B4 leupeptin 22% inactivation at 0.2 mM Mus musculus
3.4.21.B4 PefablocSC 44% inactivation at 1 mM Homo sapiens
3.4.21.B4 PefablocSC 94% inactivation at 1 mM Mus musculus
3.4.21.B4 Phe-Pro-Arg-chloromethyl ketone 98% inactivation at 0.1 mM Homo sapiens
3.4.21.B4 Phe-Pro-Arg-chloromethyl ketone complete inactivation at 0.1 mM Mus musculus
3.4.21.B4 second carboxy-terminal Kunitz-type domain of bikunin
-
 Homo sapiens
3.4.21.B4 second carboxy-terminal Kunitz-type domain of bikunin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B4 Protein + H2O Mus musculus
-
 ?
-
 ?
3.4.21.B4 Protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B4 Homo sapiens
-
-
-
3.4.21.B4 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B4
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B4 NK cell
-
 Mus musculus
-
3.4.21.B4 T-cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B4 additional information no substrates: Boc-Ala-Ala-Met-thiobenzyl ester and Boc-Ala-Ala-Asp-thiobenzyl ester Mus musculus ?
-
 ?
3.4.21.B4 Nalpha-benzyloxycarbonyl-L-Arg-thiobenzyl ester
-
 Mus musculus ?
-
 ?
3.4.21.B4 Nalpha-benzyloxycarbonyl-L-Arg-thiobenzyl ester
-
 Homo sapiens ?
-
 ?
3.4.21.B4 Nalpha-benzyloxycarbonyl-L-Lys-thiobenzyl ester
-
 Mus musculus ?
-
 ?
3.4.21.B4 Nalpha-benzyloxycarbonyl-L-Lys-thiobenzyl ester
-
 Homo sapiens ?
-
 ?
3.4.21.B4 Protein + H2O
-
 Mus musculus ?
-
 ?
3.4.21.B4 Protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B4 GzmK
-
 Mus musculus
3.4.21.B4 GzmK
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.B4 0.000022
-
 second carboxy-terminal Kunitz-type domain of bikunin pH 7.6 Mus musculus
3.4.21.B4 0.000027
-
 second carboxy-terminal Kunitz-type domain of bikunin pH 7.6 Homo sapiens
3.4.21.B4 0.000033
-
 bikunin pH 7.6 Mus musculus
3.4.21.B4 0.00006
-
 bikunin pH 7.6 Homo sapiens