EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.B1 | alpha1-proteinase | less efficient inhibition | Homo sapiens | |
3.4.21.B1 | alpha2-antiplasmin | most efficient inhibition | Homo sapiens | |
3.4.21.B1 | Aprotinin | most efficient inhibition | Homo sapiens | |
3.4.21.B1 | C1-esterase inhibitor | less efficient inhibition | Homo sapiens | |
3.4.21.B1 | Co2+ | inhibits at 2 mM | Homo sapiens | |
3.4.21.B1 | Cu2+ | inhibits at 2 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.B1 | 0.56 | - |
DL-pyroglutamic acid-cyclohexylglycine-Arg 4-nitroanilide | pH 8.2, 37°C | Homo sapiens | |
3.4.21.B1 | 0.58 | - |
D-Phe-Pip-Arg-4-nitroanilide | pH 8.2, 37°C | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.B1 | Ca2+ | strong dependence, 3.5-4fold increase of activity at 1 mM | Homo sapiens | |
3.4.21.B1 | Mg2+ | activates at 2 mM | Homo sapiens | |
3.4.21.B1 | Mn2+ | activates at 2 mM | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.21.B1 | 30000 | - |
1 * 50000 + 1 * 30000, SDS-PAGE | Homo sapiens |
3.4.21.B1 | 50000 | - |
1 * 50000 + 1 * 30000, SDS-PAGE | Homo sapiens |
3.4.21.B1 | 70000 | - |
PAGE under non-denaturating conditions | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B1 | Protein + H2O | Homo sapiens | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.B1 | Homo sapiens | Q14520 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.B1 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.B1 | plasma | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B1 | benzoyl-Ile-Glu(gamma-OR)-Gly-Arg-4-nitroanilide + H2O | i.e. A-2222, weak chromogenic substrate | Homo sapiens | benzoyl-Ile-Glu(gamma-OR)-Gly-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | CH2SO2-D-cyclohexylalanine-butanoyl-Arg-4-nitroanilide + H2O | i.e. Pefa-5979, chromogenic substrate | Homo sapiens | CH2SO2-D-cyclohexylalanine-butanoyl-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | CH2SO2-D-cyclohexylglycine-Gly-Arg-4-nitroanilide | i.e. Pefa-3107, chromogenic substrate | Homo sapiens | CH2SO2-D-cyclohexylglycine-Gly-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | CH3-OCO-D-cyclohexylalanine-Gly-Arg-4-nitroanilide + H2O | i.e. Pefa-5523, chromogenic substrate | Homo sapiens | CH3-OCO-D-cyclohexylalanine-Gly-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | D-Ala-cyclohexyltyrosine-Lys-4-nitroanilide + H2O | i.e. Pefa-5329, weak chromogenic substrate | Homo sapiens | D-Ala-cyclohexyltyrosine-Lys + 4-nitroaniline | - |
? | |
3.4.21.B1 | D-cyclohexylglycine-Ala-Arg-4-nitroanilide + H2O | i.e. Pefa-5114, good chromogenic substrate | Homo sapiens | D-cyclohexylglycine-Ala-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | D-Lys(benzyloxycarbonyl)-Pro-Arg-4-nitroanilide + H2O | i.e. Pefa-5773, chromogenic substrate | Homo sapiens | D-Lys(benzyloxycarbonyl)-Pro-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | D-Phe-Pip-Arg-4-nitroanilide + H2O | i.e. S-2238, chromogenic substrate | Homo sapiens | D-Phe-Pip-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | DL-pyroglutamic acid-cyclohexylglycine-Arg-4-nitroanilide + H2O | i.e. Pefa-3297, good chromogenic substrate | Homo sapiens | DL-pyroglutamic acid-cyclohexylglycine-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | L-pyroglutamic acid-Pro-Arg-4-nitroanilide + H2O | i.e. S-2366, chromogenic substrate | Homo sapiens | L-pyroglutamic acid-Pro-Arg + 4-nitroaniline | - |
? | |
3.4.21.B1 | Protein + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B1 | Z-D-Arg-Gly-Arg-4-nitroanilide + H2O | i.e. S-2765, good chromogenic substrate | Homo sapiens | Z-D-Arg-Gly-Arg + 4-nitroaniline | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.B1 | dimer | 1 * 50000 + 1 * 30000, SDS-PAGE | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.B1 | 0.00000088 | - |
Aprotinin | pH 8.2, 37°C | Homo sapiens |