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Literature summary extracted from

  • Cao, W.; Baniecki, M.L.; McGrath, W.J.; Bao, C.; Deming, C.B.; Rade, J.J.; Lowenstein, C.J.; Mangel, W.F.
    Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo (2003), FASEB J., 17, 2345-2346.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.39 medicine NO may be a useful antiadenovirus agent, inhibits adenovirus replication by targeting the adenovirus proteinase. Treatment of infectious virus by 2,2'-(hydroxynitrosohydrazono)bis-ethaneamine dramatically decreases viral infectivity unidentified adenovirus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.39 2,2'-(hydroxynitrosohydrazono)bis-ethaneamine NO generated from 2,2'-(hydroxynitrosohydrazono)bis-ethaneamine inhibits unidentified adenovirus
3.4.22.39 N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine NO generated from N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine inhibits the enzyme unidentified adenovirus
3.4.22.39 NO inhibits adenovirus replication by targeting the adenovirus proteinase, inhibition is reversible with dithiothreitol unidentified adenovirus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.39 unidentified adenovirus
-
-
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.39 0.47
-
NO
-
unidentified adenovirus