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Literature summary extracted from

  • Muszynska, A.; Wolczynski, S.; Palka, J.
    The mechanism for anthracycline-induced inhibition of collagen biosynthesis (2001), Eur. J. Pharmacol., 411, 17-25.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.9 daunorubicin a cytotoxic anthracycline, inhibits the enzyme and collagen biosynthesis, inhibition mechanism might act via chelating of essential Mn2+ ions, more effective than doxorubicin, also inhibits DNA synthesis Homo sapiens
3.4.13.9 doxorubicin a cytotoxic anthracycline, inhibits the enzyme and collagen biosynthesis, inhibition mechanism might act via chelating of essential Mn2+ ions, less effective than daunorubicin, also inhibits DNA synthesis Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.9 Mn2+ dependent on, metallopeptidase, complex formation with anthracyclines Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.13.9 additional information Homo sapiens the enzyme is involved in collagen metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.9 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.13.9 hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro cleaves imidodipeptides containing C-terminal proline providing a large amount of proline for collagen resynthesis Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.9 skin fibroblast cell culture Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.9 Gly-Pro + H2O
-
 Homo sapiens Gly + Pro
-
 ?
3.4.13.9 additional information the enzyme is involved in collagen metabolism Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.13.9 More enzyme belongs to the methionyl amino peptidase family M24, fomerly EC 3.4.3.7 Homo sapiens
3.4.13.9 prolidase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.13.9 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.13.9 7.8
-
 assay at Homo sapiens