Literature summary extracted from

Gray, C.W.; Ward, R.V.; Karran, E.; Turconi, S.; Rowles, A.; Viglienghi, D.; Southan, C.; Barton, A.; Fantom, K.G.; West, A.; Savopoulos, J.; Hassan, N.J.; Clinkenbeard, H.; Hanning, C.; Amegadzie, B.; Davis, J.B.; Dingwall, C.; Livi, G.P.; Creasy, C.L.
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response (2000), Eur. J. Biochem., 267, 5699-5710.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.21.108	-	Mus musculus
3.4.21.108	-	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.21.108	S306A	mutant with abolished autoproteolysis	Homo sapiens

General Stability

EC Number	General Stability	Organism
3.4.21.108	enzyme undergoes autoproteolysis	Mus musculus
3.4.21.108	enzyme undergoes autoproteolysis	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.108	diisopropylfluorophosphate	complete inhibition at 4 mM	Homo sapiens
3.4.21.108	N-tosyllysine chloromethyl ketone	51% inhibition at 5 mM	Homo sapiens
3.4.21.108	phenylmethanesulfonyl fluoride	51% inhibition at 5 mM	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.108	nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.108	additional information	Mus musculus	role in apoptosis	?	-	?
3.4.21.108	additional information	Homo sapiens	role in apoptosis	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.108	Homo sapiens	O43464	-	-
3.4.21.108	Mus musculus	Q9JIY5	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.21.108	-	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.108	brain	-	Homo sapiens	-
3.4.21.108	heart	-	Homo sapiens	-
3.4.21.108	skeletal muscle	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.108	alpha-casein + H2O	-	Homo sapiens	?	-	?
3.4.21.108	beta-casein + H2O	-	Mus musculus	?	-	?
3.4.21.108	beta-casein + H2O	-	Homo sapiens	?	-	?
3.4.21.108	additional information	role in apoptosis	Mus musculus	?	-	?
3.4.21.108	additional information	role in apoptosis	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.108	HtrA2	-	Mus musculus
3.4.21.108	HtrA2	-	Homo sapiens

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Release 2023.1 (January 2023)