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Literature summary extracted from

  • Atencia, E.A.; Madrid, O.; Gunther Sillero, M.A.; Sillero, A.
    T4 RNA ligase catalyzes the synthesis of dinucleoside polyphosphates (1999), Eur. J. Biochem., 261, 802-811.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.3 tripolyphosphate
-
 Tequatrovirus T4

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.3 ATP + (ribonucleotide)n + (ribonucleotide)m Tequatrovirus T4 catalyzes the transfer of AMP from the E-AMP complex to diverse compounds, generating the product indicated between parentheses, ATP(Ap4A), NTP (Ap4N), P3 or P4 (p4A or p5A), ADP (Ap3A) AMP + diphosphate + (ribonucleotide)n+m
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.3 Tequatrovirus T4
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.5.1.3 0.06
-
-
 Tequatrovirus T4

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.3 ATP + (ribonucleotide)n + (ribonucleotide)m
-
 Tequatrovirus T4 AMP + diphosphate + (ribonucleotide)n+m
-
 ?
6.5.1.3 ATP + (ribonucleotide)n + (ribonucleotide)m catalyzes the transfer of AMP from the E-AMP complex to diverse compounds, generating the product indicated between parentheses, ATP(Ap4A), NTP (Ap4N), P3 or P4 (p4A or p5A), ADP (Ap3A) Tequatrovirus T4 AMP + diphosphate + (ribonucleotide)n+m
-
 ?
6.5.1.3 ATP + ATP
-
 Tequatrovirus T4 P1,P4-bis(5'-adenosyl) tetraphosphate + diphosphate
-
 ?
6.5.1.3 ATP + ATP
-
 Tequatrovirus T4 P1,P3-bis(5'-adenosyl) triphosphate + ?
-
 ?
6.5.1.3 ATPgammaS + ATP
-
 Tequatrovirus T4 P1,P4-bis(5'-adenosyl) tetraphosphate + thiodiphosphate
-
 ?
6.5.1.3 GTP + ATP
-
 Tequatrovirus T4 P1-(5'-adenosyl),P4-(5'-guanosyl) tetraphosphate + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.3 T4 RNA ligase
-
 Tequatrovirus T4

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.5.1.3 0.017
-
 GTP pH 7.4, 37°C Tequatrovirus T4
6.5.1.3 0.055
-
 ATP pH 7.4, 30°C, ATP as acceptor of AMP, Ap4A synthesis Tequatrovirus T4

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5.1.3 7.4
-
-
 Tequatrovirus T4

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.5.1.3 6.5 8 around 70% of the maximum at pH 8.0 Tequatrovirus T4