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Literature summary extracted from

  • Kraemer, F.B.; Shen, W.J.; Natu, V.; Patel, S.; Osuga, J.; Ishibashi, S.; Azhar, S.
    Adrenal neutral cholesteryl ester hydrolase: identification, subcellular distribution, and sex differences (2002), Endocrinology, 143, 801-806.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.13 additional information inactivation of the hormone-sensitive lipase HSL by homologous recombination leads to 98% reduction of cholesteryl esterase activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 additional information inactivation of the hormone-sensitive lipase HSL by homologous recombination leads to 98% reduction of cholesteryl esterase activity Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.13 cytosol low activity Rattus norvegicus 5829
-
3.1.1.13 microsome main activity Rattus norvegicus
-
-
3.1.1.13 mitochondrion low activity Rattus norvegicus 5739
-
3.1.1.13 nucleus low activity Rattus norvegicus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Rattus norvegicus
-
 activity in male rats is higher than in female rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 adrenal gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.13 0.00025
-
 female rat mutant lacking HSL activity Rattus norvegicus
3.1.1.13 0.00032
-
 male rat mutant lacking HSL activity Rattus norvegicus
3.1.1.13 0.016
-
 femal rat adrenal Rattus norvegicus
3.1.1.13 0.028
-
 male rat adrenal Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl oleate + H2O
-
 Rattus norvegicus cholesterol + oleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 CEH
-
 Rattus norvegicus
3.1.1.13 neutral cholesteryl ester hydrolase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.13 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.13 7
-
 assay at Rattus norvegicus