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Literature summary extracted from

  • Chen, J.; Chiang, Y.C.; Denis, C.L.
    CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase (2002), EMBO J., 21, 1414-1426.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.13.4 D713A significant reduction of enzymic activity Saccharomyces cerevisiae
3.1.13.4 D780A significant reduction of enzymic activity Saccharomyces cerevisiae
3.1.13.4 E556A complete loss of activity, E556 is the key Mg2+-binding residue Saccharomyces cerevisiae
3.1.13.4 H818A significant reduction of enzymic activity Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
3.1.13.4 Saccharomyces cerevisiae
-
 enzyme contains both RNA and single-stranded DNA 3’-5’-exonuclease activities
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.13.4 poly(A)-mRNA + H2O
-
 Saccharomyces cerevisiae 5'-AMP
-
 ?
3.1.13.4 poly(a)-ssDNA + H2O
-
 Saccharomyces cerevisiae 5'-dAMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.13.4 CCR4
-
 Saccharomyces cerevisiae
3.1.13.4 cytoplasmic deadenylase
-
 Saccharomyces cerevisiae