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Literature summary extracted from

  • Izumi, Y.; Hirata, M.; Hasuwa, H.; Iwamoto, R.; Umata, T.; Miyado, K.; Tamai, Y.; Kurisaki, T.; Sehara-Fujisawa, A.; Ohno, S.; Mekada, E.
    A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor (1998), EMBO J., 17, 7260-7272.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.B9 Protein kinase C binds to the enzyme at its cytoplasmic part and cooperates in cleavage of EGF-like growth factor Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B9 expression of GST-linked cytoplasmic region in Escherichia coli, coeexpression of the enzyme and protein kinase C in COS-7 cells, overexpression of wild-type and deletion mutants in Vero-H cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B9 additional information construction of several deletion mutants lacking amino acids of the cytoplasmic region by site-directed mutagenesis Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.B9 12000
-
 x * 84000, processed enzyme, x * 12000, enzyme proform, SDS-PAGE Mus musculus
3.4.24.B9 84000
-
 x * 84000, processed enzyme, x * 12000, enzyme proform, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B9 heparin-binding EGF-like growth factor + H2O Mus musculus cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding heparin-binding EGF-like growth factor fragment soluble product ?
3.4.24.B9 pro-heparin-binding EGF-like growth factor + H2O Mus musculus cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding ?
-
 ?
3.4.24.B9 proteins + H2O Mus musculus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B9 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B9 proteolytic modification
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B9 heparin-binding EGF-like growth factor + H2O cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding Mus musculus heparin-binding EGF-like growth factor fragment soluble product ?
3.4.24.B9 pro-heparin-binding EGF-like growth factor + H2O cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding Mus musculus ?
-
 ?
3.4.24.B9 proteins + H2O
-
 Mus musculus peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.B9 ? x * 84000, processed enzyme, x * 12000, enzyme proform, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B9 ADAM9
-
 Mus musculus
3.4.24.B9 M12.209 Merops-ID Mus musculus
3.4.24.B9 MDC9
-
 Mus musculus
3.4.24.B9 MDC9/meltrin-gamma/ADAM9
-
 Mus musculus
3.4.24.B9 meltrin-gamma
-
 Mus musculus