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Literature summary extracted from

  • Vessey, D.A.
    Isolation and preliminary characterization of the medium-chain fatty acid:CoA ligase responsible for activation of short- and medium-chain fatty acids in colonic mucosa from swine (2001), Dig. Dis. Sci., 46, 438-442.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.2 cyclohexane carboxylate
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.2 0.108
-
Octanoate
-
Sus scrofa
6.2.1.2 0.731
-
Butyrate
-
Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.2 K+ increases activity 10fold Sus scrofa
6.2.1.2 Mg2+ absolute requirement Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.2 46500
-
gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.2 colonic mucosa
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.2 ATP + benzoate + CoA 0.3% of the activity with octanoate Sus scrofa AMP + diphosphate + benzoyl-CoA
-
?
6.2.1.2 ATP + butyrate + CoA 46% of the activity with octanoate Sus scrofa AMP + diphosphate + butyryl-CoA
-
?
6.2.1.2 ATP + decanoate + CoA 48% of the activity with octanoate Sus scrofa AMP + diphosphate + decanoyl-CoA
-
?
6.2.1.2 ATP + hexanoate + CoA 15% of the activity with octanoate Sus scrofa AMP + diphosphate + hexanoyl-CoA
-
?
6.2.1.2 ATP + laurate + CoA 12.6% of the activity with octanoate Sus scrofa AMP + diphosphate + lauroyl-CoA
-
?
6.2.1.2 ATP + octanoate + CoA
-
Sus scrofa AMP + diphosphate + octanoyl-CoA
-
?
6.2.1.2 ATP + propionate + CoA 2% of the activity with octanoate Sus scrofa AMP + diphosphate + propionyl-CoA
-
?
6.2.1.2 ATP + valerate + CoA 9.9% of the activity with octanoate Sus scrofa AMP + diphosphate + valeryl-CoA
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.2 7
-
reaction with butyrate as substrate Sus scrofa
6.2.1.2 8.6
-
reaction with octanoate as substrate Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.2.1.2 0.17
-
cyclohexane carboxylate reaction with butyrate as substrate Sus scrofa