Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Atkinson, L.L.; Kelly, S.E.; Russell, J.C.; Bar-Tana, J.; Lopaschuk, G.D.
    MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats (2002), Diabetes, 51, 1548-1555.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 additional information 3,3,14,14-tetramethylhexanedecadienoic acid treatment if animals inhibits activity in liver by activation of AMP-activated protein kinase, no effect in muscle Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3- Rattus norvegicus key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation ADP + phosphate + malonyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus
-
 insulin resistant strain JCR:LA-cp and wild type rats
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.4.1.2 phosphoprotein AMP-activated protein kinase phosphorylates and inactivates enzyme activity in liver Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.2 additional information
-
 no differences in activity in muscle Rattus norvegicus
6.4.1.2 0.00033
-
 wild type rat liver, 37°C Rattus norvegicus
6.4.1.2 0.00875
-
 JCR:LA-cp rat liver, 37°C Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis, key regulator of muscle fatty acid oxidation Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 biotin enzyme-bound Rattus norvegicus