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Literature summary extracted from

  • Gould, W.R.; Leadley, R.J.
    Recent advances in the discovery and development of direct coagulation factor Xa inhibitors (2003), Curr. Pharm. Des., 9, 2337-2347.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.6 medicine enzyme is a target for discovery, design of direct inhibitors and development of antithrombotic agents, overview Homo sapiens
3.4.21.6 pharmacology enzyme is a target for discovery, design of direct inhibitors and development of antithrombotic agents, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.6 prothrombin + H2O Homo sapiens enzyme is involved in thrombotic complications of artherosclerosis and following diseases, overview thrombin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.6 selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?
3.4.21.6 prothrombin + H2O enzyme is involved in thrombotic complications of artherosclerosis and following diseases, overview Homo sapiens thrombin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 factor Xa
-
 Homo sapiens
3.4.21.6 More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens