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Literature summary extracted from
- Non-hemostatic activity of coagulation factor Xa: potential implications for various diseases (2001), Curr. Opin. Pharmacol., 1, 169-175.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.6 | medicine | enzyme is a target for antithrombotic agents | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.6 | extracellular | - |
Homo sapiens | - |
- |
| 3.4.21.6 | extracellular | - |
Rattus norvegicus | - |
- |
| 3.4.21.6 | extracellular | - |
Sus scrofa | - |
- |
| 3.4.21.6 | extracellular | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.6 | additional information | Homo sapiens | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | ? | - |
? |  |
| 3.4.21.6 | additional information | Rattus norvegicus | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | ? | - |
? | |
| 3.4.21.6 | additional information | Sus scrofa | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | ? | - |
? | |
| 3.4.21.6 | additional information | Oryctolagus cuniculus | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | Sus scrofa | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | Oryctolagus cuniculus | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | Homo sapiens | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | Rattus norvegicus | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells | thrombin + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.6 | Homo sapiens | - |
- |
- |
| 3.4.21.6 | Oryctolagus cuniculus | - |
- |
- |
| 3.4.21.6 | Rattus norvegicus | - |
- |
- |
| 3.4.21.6 | Sus scrofa | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.21.6 | selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens | |
| 3.4.21.6 | selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Rattus norvegicus | |
| 3.4.21.6 | selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Sus scrofa | |
| 3.4.21.6 | selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Oryctolagus cuniculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.6 | blood | - |
Homo sapiens | - |
| 3.4.21.6 | blood | - |
Rattus norvegicus | - |
| 3.4.21.6 | blood | - |
Sus scrofa | - |
| 3.4.21.6 | blood | - |
Oryctolagus cuniculus | - |
| 3.4.21.6 | blood clot | bound to | Homo sapiens | - |
| 3.4.21.6 | blood clot | bound to | Rattus norvegicus | - |
| 3.4.21.6 | blood clot | bound to | Sus scrofa | - |
| 3.4.21.6 | blood clot | bound to | Oryctolagus cuniculus | - |
| 3.4.21.6 | additional information | factor Xa binds to cell surfaces | Homo sapiens | - |
| 3.4.21.6 | additional information | factor Xa binds to cell surfaces | Rattus norvegicus | - |
| 3.4.21.6 | additional information | factor Xa binds to cell surfaces | Sus scrofa | - |
| 3.4.21.6 | additional information | factor Xa binds to cell surfaces | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.6 | additional information | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | Homo sapiens | ? | - |
? | |
| 3.4.21.6 | additional information | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | Rattus norvegicus | ? | - |
? | |
| 3.4.21.6 | additional information | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | Sus scrofa | ? | - |
? | |
| 3.4.21.6 | additional information | enzyme link between cancer and thrombosis appears to be a bidirectional relationship, physiological role of factor Xa, involvement in inflammation and diseases, physiological interactions, regulation, overview | Oryctolagus cuniculus | ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | - |
Rattus norvegicus | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | - |
Sus scrofa | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | - |
Oryctolagus cuniculus | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces | Sus scrofa | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces | Oryctolagus cuniculus | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells | Homo sapiens | thrombin + ? | - |
? | |
| 3.4.21.6 | prothrombin + H2O | enzyme plays a key role in thrombosis and hemostasis by cleaving prothrombin to thrombin and thereby regulating the generation of this vital procoagulant enzyme, thrombus formation causes diseases like arterial restenosis, induces mitogenic signaling via binding to effector cell protease receptor-1, i.e. EPR-1, on cell surfaces, and via release of platelet-derived growth factor PDGF in aortic smooth-muscle cells | Rattus norvegicus | thrombin + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.6 | coagulation factor Xa | - |
Homo sapiens |
| 3.4.21.6 | coagulation factor Xa | - |
Rattus norvegicus |
| 3.4.21.6 | coagulation factor Xa | - |
Sus scrofa |
| 3.4.21.6 | coagulation factor Xa | - |
Oryctolagus cuniculus |
| 3.4.21.6 | factor Xa | - |
Homo sapiens |
| 3.4.21.6 | factor Xa | - |
Rattus norvegicus |
| 3.4.21.6 | factor Xa | - |
Sus scrofa |
| 3.4.21.6 | factor Xa | - |
Oryctolagus cuniculus |
| 3.4.21.6 | FXa | - |
Homo sapiens |
| 3.4.21.6 | FXa | - |
Rattus norvegicus |
| 3.4.21.6 | FXa | - |
Sus scrofa |
| 3.4.21.6 | FXa | - |
Oryctolagus cuniculus |
| 3.4.21.6 | More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
| 3.4.21.6 | More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Rattus norvegicus |
| 3.4.21.6 | More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Sus scrofa |
| 3.4.21.6 | More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Oryctolagus cuniculus |
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