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Literature summary extracted from

  • Biancone, L.; Cantaluppi, V.; Del Sorbo, L.; Russo, S.; Tjoelker, L.W.; Camussi, G.
    Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth (2003), Clin. Cancer Res., 9, 4214-4220.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.47
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Mus musculus i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-
3.1.1.47 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 B16-F10 cell melanoma cell line, implanted in syngenic C57BI/6J mice which then show reduced vascularization and growth Mus musculus
-
3.1.1.47 KS-IMM cell Kaposi's sarcoma cell line, implanted into SCID mice which then show reduced vascularization and growth Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Mus musculus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases Mus musculus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information enzyme of melanoma cell line inhibits neoangiogenesis and endothelial tubulogenesis in vitro, overview Mus musculus ?
-
 ?
3.1.1.47 additional information enzyme of sarcoma cell line inhibits neoangiogenesis and endothelial tubulogenesis in vitro, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 PAF-AH
-
 Mus musculus
3.1.1.47 PAF-AH
-
 Homo sapiens
3.1.1.47 platelet-activating factor acetyl-hydrolase
-
 Mus musculus
3.1.1.47 platelet-activating factor acetyl-hydrolase
-
 Homo sapiens