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Literature summary extracted from

  • Xie, Y.; Meier, K.E.
    Lysophospholipase D and its role in LPA production (2004), Cell. Signal., 16, 975-981.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.39 Co2+ extracellular enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.39 1,10-phenanthroline extracellular enzyme Homo sapiens
3.1.4.39 ATP extracellular enzyme Homo sapiens
3.1.4.39 Cu2+ the inhibition of extracellular enzyme can be prevented by 2,6-di-tert-butyl-4-hydroxy-methylphenol Rattus norvegicus
3.1.4.39 EDTA extracellular enzyme Homo sapiens
3.1.4.39 EDTA inhibition of extracellular enzyme Rattus norvegicus
3.1.4.39 p-hydroxymercuribenzoate the inhibition of the microsomal enzyme can be prevented by glutathione and dithiothreitol Rattus norvegicus
3.1.4.39 serine esterase inhibitors inhibition of extracellular enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.39 extracellular
-
Homo sapiens
-
-
3.1.4.39 extracellular
-
Rattus norvegicus
-
-
3.1.4.39 microsome
-
Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.39 Ca2+
-
Oryctolagus cuniculus
3.1.4.39 Ca2+ microsomal enzyme Rattus norvegicus
3.1.4.39 Co2+ extracellular enzyme Rattus norvegicus
3.1.4.39 Mg2+ low effect in rabbit kidney Oryctolagus cuniculus
3.1.4.39 Mg2+ microsomal enzyme Rattus norvegicus
3.1.4.39 Mn2+ extracellular enzyme Rattus norvegicus
3.1.4.39 Ni2+ extracellular enzyme Rattus norvegicus
3.1.4.39 Zn2+ extracellular enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 additional information Rattus norvegicus the product lysophosphatidic acid mediates multiple biological functions ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Bos taurus
-
-
-
3.1.4.39 Homo sapiens
-
-
-
3.1.4.39 Oryctolagus cuniculus
-
-
-
3.1.4.39 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.39
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 adipose tissue medium of cultured adipocytes Homo sapiens
-
3.1.4.39 brain
-
Rattus norvegicus
-
3.1.4.39 epithelial cell
-
Rattus norvegicus
-
3.1.4.39 gastric mucosa
-
Rattus norvegicus
-
3.1.4.39 kidney
-
Oryctolagus cuniculus
-
3.1.4.39 liver
-
Rattus norvegicus
-
3.1.4.39 plasma
-
Homo sapiens
-
3.1.4.39 plasma
-
Rattus norvegicus
-
3.1.4.39 plasma
-
Oryctolagus cuniculus
-
3.1.4.39 testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 1-alkyl-sn-glycero-3-phosphocholine + H2O
-
Rattus norvegicus 1-alkyl-sn-glycero-3-phosphate + choline
-
?
3.1.4.39 1-O-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + H2O the microsomal enzyme Rattus norvegicus 1-O-alkyl-2-lyso-sn-glycero-3-phosphate + ethanolamine the microsomal enzyme ?
3.1.4.39 additional information the microsomal enzymes prefer alkyl-lysophospholipids, the extracellular enzyme prefer acyl-phospholipids, but can use alkyl-lysophospholipids Rattus norvegicus ?
-
?
3.1.4.39 additional information the plasma enzyme hydrolyzes acyl-, alkyl- and alkenyl-lysophophatidylcholines Homo sapiens ?
-
?
3.1.4.39 additional information the product lysophosphatidic acid mediates multiple biological functions Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 More molecular identity of autotoxin and enzyme Homo sapiens