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Literature summary extracted from
- Intragenic complementation and the structure and function of argininosuccinate lyase (2000), Cell. Mol. Life Sci., 57, 1637-1651.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 4.3.2.1 | ASL undergoes cold dissociation via a dimer intermediate | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.3.2.1 | citrulline | noncompetitive vs. fumarate and arginine | Homo sapiens |  |
| 4.3.2.1 | succinate | noncompetitive vs. fumarate and arginine | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.3.2.1 | 0.2 | - |
argininosuccinate | - |
Homo sapiens | |
| 4.3.2.1 | 3 | - |
arginine | - |
Homo sapiens | |
| 4.3.2.1 | 5.3 | - |
fumarate | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.3.2.1 | cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.3.2.1 | 51600 | - |
4 * 51600, deduced from nucleotide sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.2.1 | (Nomega-L-arginino)succinate | Homo sapiens | - |
fumarate + L-arginine | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.3.2.1 | Homo sapiens | - |
mutations in ASL result the clinical condition argininosuccinate aciuria | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.3.2.1 | liver ASL | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.3.2.1 | brain | - |
Homo sapiens | - |
| 4.3.2.1 | erythrocyte | - |
Homo sapiens | - |
| 4.3.2.1 | heart | - |
Homo sapiens | - |
| 4.3.2.1 | kidney | - |
Homo sapiens | - |
| 4.3.2.1 | liver | predominant expression | Homo sapiens | - |
| 4.3.2.1 | muscle | - |
Homo sapiens | - |
| 4.3.2.1 | pancreas | - |
Homo sapiens | - |
| 4.3.2.1 | skin fibroblast | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.3.2.1 | 8 | - |
synthesis of argininosuccinate | Homo sapiens |
| 4.3.2.1 | 10.3 | - |
deamination of argininosuccinate | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.2.1 | (Nomega-L-arginino)succinate | - |
Homo sapiens | fumarate + L-arginine | - |
? | |
| 4.3.2.1 | (Nomega-L-arginino)succinate | - |
Homo sapiens | fumarate + L-arginine | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.3.2.1 | tetramer | 4 * 51600, deduced from nucleotide sequence | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.3.2.1 | ASL | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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