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Literature summary extracted from

  • DeBose-Boyd, R.A.; Brown, M.S.; Li, W.P.; Nohturfft, A.; Goldstein, J.L.; Espenshade, P.J.
    Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi (1999), Cell, 99, 703-712.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.112 truncated from lacking the COOH-terminal membrane anchor, expressed in CHO cells Cricetulus griseus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.112 Golgi apparatus cis-and medial-Golgi, but not in the trans-Golgi Cricetulus griseus 5794
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3.4.21.112 membrane
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 Cricetulus griseus 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.112 additional information Cricetulus griseus initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholersterol and unsaturated fatty acids in animal cells ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.112 Cricetulus griseus
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-
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.112 proteolytic modification SP1-A is inactive and undergoes autocatalytic processing, generating an active form S1P-B, which is further cleaved after residue 186 to generate S1P-C Cricetulus griseus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.112 additional information initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholersterol and unsaturated fatty acids in animal cells Cricetulus griseus ?
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 ?
3.4.21.112 sterol regulatory element-binding protein + H2O SREBP, cleaves the luminal loop following the tetrapeptide sequence Arg-Xaa-Xaa-Leu Cricetulus griseus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.112 S1P
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 Cricetulus griseus