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Literature summary extracted from

  • Brooks, P.C.; Silletti, S.; von Schalscha, T.L.; Friedlander, M.; Cheresh, D.A.
    Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity (1998), Cell, 92, 391-400.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B15 additional information Gallus gallus interacts with integrin alphavbeta3, natural inhibitor of matrix metalloprotease 2, i.e. MMP-2, thereby regulating the invasive behavior of new blood vessels, enzyme domain disrupts angiogenesis and tumor growth ?
-
 ?
3.4.24.B15 protein + H2O Gallus gallus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B15 Gallus gallus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B15 proteolytic modification the 29 kDa hemopexin domain of MMP-2 is cleaved of its C-terminus during processing of MMP-2, as well as a 80 amino acid sequence of the N-terminus Gallus gallus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.B15 proteolytic degradation of proteins regulatory inhibition of matrix metalloprotease 2 Gallus gallus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B15 blood vessel associated on the surface of Gallus gallus
-
3.4.24.B15 chorioallantois
-
 Gallus gallus
-
3.4.24.B15 embryo
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B15 additional information enzyme domain prevents the matrix metalloprotease 2 of binding to integrin alphavbeta3 and blocks cell surface collagenolytic activity Gallus gallus ?
-
 ?
3.4.24.B15 additional information interacts with integrin alphavbeta3, natural inhibitor of matrix metalloprotease 2, i.e. MMP-2, thereby regulating the invasive behavior of new blood vessels, enzyme domain disrupts angiogenesis and tumor growth Gallus gallus ?
-
 ?
3.4.24.B15 protein + H2O
-
 Gallus gallus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B15 M13.091 Merops-ID Gallus gallus
3.4.24.B15 matrix metalloprotease 2 C-terminal hemopexin-like domain
-
 Gallus gallus
3.4.24.B15 PEX
-
 Gallus gallus