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Literature summary extracted from

  • Sun, X.; Yang, Z.; Li, S.; Tan, Y.; Zhang, N.; Wang, X.; Yagi, S.; Yoshioka, T.; Takimoto, A.; Mitsushima, K.; Suginaka, A.; Frenkel, E.P.; Hoffman, R.M.
    In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation (2003), Cancer Res., 63, 8377-8383.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.11 medicine rMETase is an enzyme active in preclinical mouse models of human cancer Pseudomonas putida

General Stability

EC Number General Stability Organism
4.4.1.11 plasma half-life of polyethylene glycolylated rMETase in mice increases from 2 h for naked rMETase to 38 h for polyethylene glycolylated rMETase Pseudomonas putida

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.11 L-methionine + H2O Pseudomonas putida
-
 methanethiol + NH3 + 2-oxobutanoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.11 Pseudomonas putida
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.11 recombinant rMETase Pseudomonas putida

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.11 L-methionine + H2O
-
 Pseudomonas putida methanethiol + NH3 + 2-oxobutanoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.11 rMETase
-
 Pseudomonas putida

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.11 pyridoxal 5'-phosphate
-
 Pseudomonas putida