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Literature summary extracted from

  • Han, S.Y.; Kato, H.; Kato, S.; Suzuki, T.; Shibata, H.; Ishii, S.; Shiiba, K.I.; Matsuno, S.; Kanamaru, R.; Ishioka, C.
    Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay (2000), Cancer Res., 60, 3147-3151.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.67 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.67 A121P inactive mutant enzyme Homo sapiens
3.1.3.67 C105F inactive mutant enzyme Homo sapiens
3.1.3.67 C124R inactive mutant enzyme Homo sapiens
3.1.3.67 C136Y inactive mutant enzyme Homo sapiens
3.1.3.67 C71Y inactive mutant enzyme Homo sapiens
3.1.3.67 D107Y inactive mutant enzyme Homo sapiens
3.1.3.67 D331G mutant enzyme with partial activity Homo sapiens
3.1.3.67 F342N mutant enzyme with partial activity Homo sapiens
3.1.3.67 F347L mutant enzyme with partial activity Homo sapiens
3.1.3.67 G129E inactive mutant enzyme Homo sapiens
3.1.3.67 G129R inactive mutant enzyme Homo sapiens
3.1.3.67 G165R inactive mutant enzyme Homo sapiens
3.1.3.67 G20E mutant enzyme with partial activity Homo sapiens
3.1.3.67 G251C inactive mutant enzyme Homo sapiens
3.1.3.67 H61R inactive mutant enzyme Homo sapiens
3.1.3.67 H93Y inactive mutant enzyme Homo sapiens
3.1.3.67 K289E mutant enzyme with partial activity Homo sapiens
3.1.3.67 L112P inactive mutant enzyme Homo sapiens
3.1.3.67 L112R inactive mutant enzyme Homo sapiens
3.1.3.67 L345Q inactive mutant enzyme Homo sapiens
3.1.3.67 L42R activity is comparable with or even higher than that of wild-type enzyme Homo sapiens
3.1.3.67 M134L mutant enzyme with partial activity Homo sapiens
3.1.3.67 R130G inactive mutant enzyme Homo sapiens
3.1.3.67 R130L inactive mutant enzyme Homo sapiens
3.1.3.67 R130Q inactive mutant enzyme Homo sapiens
3.1.3.67 R173C inactive mutant enzyme Homo sapiens
3.1.3.67 R173H inactive mutant enzyme Homo sapiens
3.1.3.67 R173P inactive mutant enzyme Homo sapiens
3.1.3.67 S10N activity is comparable with or even higher than that of wild-type enzyme Homo sapiens
3.1.3.67 S170N inactive mutant enzyme Homo sapiens
3.1.3.67 S170R inactive mutant enzyme Homo sapiens
3.1.3.67 S227F mutant enzyme with partial activity Homo sapiens
3.1.3.67 T401I activity is comparable with or even higher than that of wild-type enzyme Homo sapiens
3.1.3.67 V133I inactive mutant enzyme Homo sapiens
3.1.3.67 V343E inactive mutant enzyme Homo sapiens
3.1.3.67 V369G activity is comparable with or even higher than that of wild-type enzyme Homo sapiens
3.1.3.67 Y155C inactive mutant enzyme Homo sapiens
3.1.3.67 Y16C inactive mutant enzyme Homo sapiens
3.1.3.67 Y174N inactive mutant enzyme Homo sapiens
3.1.3.67 Y27S inactive mutant enzyme Homo sapiens
3.1.3.67 Y68H inactive mutant enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate + H2O Homo sapiens lipid phosphatase activity of PTEN is critical for its tumor suppressor function and the enzyme negatively regulates the phosphatidylinositol 3'-kinase-protein kinase B pathway phosphatidylinositol-4,5-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.67 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.67 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.67 inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens inositol 1,4,5-trisphosphate + phosphate
-
 ?
3.1.3.67 phosphatidylinositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens phosphatidyl inositol 4,5-bisphosphate + phosphate
-
 ?
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate + H2O lipid phosphatase activity of PTEN is critical for its tumor suppressor function and the enzyme negatively regulates the phosphatidylinositol 3'-kinase-protein kinase B pathway Homo sapiens phosphatidylinositol-4,5-bisphosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.67 PTEN
-
 Homo sapiens