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Literature summary extracted from

  • Paley, E.L.
    Tryptamine-mediated stabilization of tryptophanyl-tRNA synthetase in human cervical carcinoma cell line (1999), Cancer Lett., 137, 1-7.
    View publication on PubMed

General Stability

EC Number General Stability Organism
6.1.1.2 tryptamine stabilizes and inhibits the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.2 tryptamine competitive, inhibition of the enzyme leads to inhibition of protein biosynthesis, tryptamine stabilizes the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.2 ATP + L-tryptophan + tRNATrp Homo sapiens
-
 AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.2 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.1.1.2 phosphoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.2 HeLa cell original cell line and a tryptamine-resistant subline, the latter exhibiting a lower growth rate with a higher tendency to form monolayer instead of multilayers Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.2 ATP + L-tryptophan + tRNATrp
-
 Homo sapiens AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.2 TrpRS
-
 Homo sapiens
6.1.1.2 Tryptophanyl-tRNA synthase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.2 ATP
-
 Homo sapiens