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Literature summary extracted from

  • Dong, J.F.; Moake, J.L.; Nolasco, L.; Bernardo, A.; Arceneaux, W.; Shrimpton, C.N.; Schade, A.J.; McIntire, L.V.; Fujikawa, K.; Lopez, J.A.
    ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions (2002), Blood, 100, 4033-4039.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular plasma Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.87 Ba2+ activates Homo sapiens
3.4.24.87 guanidine activates Homo sapiens
3.4.24.87 Urea activates Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O Homo sapiens rapid physiological process that occurs on endothelial surfaces, activity is reduced by 87-100% in patients with thrombotic thrombocytopenic pupura 2 peptides of 176 kD and 140 kD
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O large multimeric complexes are reduced to smaller ones, cleavage of peptide bond Tyr842-Met843 in the vWFdomain A2 Homo sapiens 2 peptides of 176 kD and 140 kD
-
 ?
3.4.24.87 von Willebrand factor + H2O rapid physiological process that occurs on endothelial surfaces, activity is reduced by 87-100% in patients with thrombotic thrombocytopenic pupura Homo sapiens 2 peptides of 176 kD and 140 kD
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS VWF cleaving metalloprotease
-
 Homo sapiens
3.4.24.87 ADAMTS13
-
 Homo sapiens
3.4.24.87 M12.241 Merops-ID Homo sapiens
3.4.24.87 VWF cleaving metalloprotease
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.87 8 9
-
 Homo sapiens