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Literature summary extracted from

  • Plaimauer, B.; Zimmermann, K.; Volkel, D.; Antoine, G.; Kerschbaumer, R.; Jenab, P.; Furlan, M.; Gerritsen, H.; Lammle, B.; Schwarz, H.P.; Scheiflinger, F.
    Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13) (2002), Blood, 100, 3626-3632.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.87 transient expression in HEK293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.87 additional information enzyme is inhibited by plasma from an individuum with acquired thrombotic thrombocytopenic pupura Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular plasma Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.87 Ba2+ activates, metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O Homo sapiens cleavage of peptide bond Tyr842-Met843, rapid degradation of multimers to smaller fragments, decreased activity results in bone marrow transplant-associated thrombotic microangiopathy and thrombotic thrombocytopenic pupura ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens Q76LX8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 brain enzyme expression Homo sapiens
-
3.4.24.87 heart enzyme expression Homo sapiens
-
3.4.24.87 kidney enzyme expression Homo sapiens
-
3.4.24.87 liver enzyme expression, adult and fetal Homo sapiens
-
3.4.24.87 muscle enzyme expression Homo sapiens
-
3.4.24.87 placenta enzyme expression Homo sapiens
-
3.4.24.87 plasma
-
 Homo sapiens
-
3.4.24.87 testis enzyme expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O cleavage of peptide bond Tyr842-Met843, native and recombinant enzyme Homo sapiens ?
-
 ?
3.4.24.87 von Willebrand factor + H2O cleavage of peptide bond Tyr842-Met843, rapid degradation of multimers to smaller fragments, decreased activity results in bone marrow transplant-associated thrombotic microangiopathy and thrombotic thrombocytopenic pupura Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
-
 Homo sapiens
3.4.24.87 M12.241 Merops-ID Homo sapiens
3.4.24.87 von Willebrand factor-cleaving protease
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.87 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.87 8
-
 assay at Homo sapiens