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Literature summary extracted from

  • Kawamura, T.; Kikuno, K.; Oda, T.; Muramatsu, T.
    Some molecular and inhibitory specifications of a dipeptidyl carboxypeptidase from the polychaete Neanthes virens resembling angiotensin I converting enzyme (2000), Biosci. Biotechnol. Biochem., 64, 2193-2200.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluene sulfonate 20 mM, 99.6% inhibition Alitta virens
3.4.15.1 2,3-butendione 10 mM, 97.4% inhibition Alitta virens
3.4.15.1 Arg-Phe IC50: 4.365 mM Alitta virens
3.4.15.1 chloramine-T 50 mM, 97.1% inhibition Alitta virens
3.4.15.1 diethyl dicarbonate 10 mM, 92.8% inhibition Alitta virens
3.4.15.1 Gly-Phe IC50: 10.471 mM Alitta virens
3.4.15.1 Gly-Trp IC50: 20.417 mM Alitta virens
3.4.15.1 Gly-Tyr IC50: 5.495 mM Alitta virens
3.4.15.1 N-bromosuccinimide 2 mM, 99.8% inhibition Alitta virens
3.4.15.1 Phe-Gly IC50: 134.9 mM Alitta virens
3.4.15.1 Tetranitromethane 5 mM, 99.1% inhibition Alitta virens
3.4.15.1 Val-Trp IC50: 3.311 mM Alitta virens
3.4.15.1 Val-Tyr IC50: 0.263 mM Alitta virens

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Alitta virens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.15.1 glycoprotein oligosaccharide content is 8% of the weight Alitta virens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 hippuryl-His-Leu + H2O
-
 Alitta virens hippuric acid + His-Leu
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.15.1 0.138
-
 Val-Trp pH 8.3, 37°C Alitta virens
3.4.15.1 0.203
-
 Val-Tyr pH 8.3, 37°C Alitta virens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.263
-
 IC50: 0.263 mM Alitta virens Val-Tyr
3.4.15.1 3.311
-
 IC50: 3.311 mM Alitta virens Val-Trp
3.4.15.1 4.365
-
 IC50: 4.365 mM Alitta virens Arg-Phe
3.4.15.1 5.495
-
 IC50: 5.495 mM Alitta virens Gly-Tyr
3.4.15.1 10.471
-
 IC50: 10.471 mM Alitta virens Gly-Phe
3.4.15.1 20.417
-
 IC50: 20.417 mM Alitta virens Gly-Trp
3.4.15.1 134.9
-
 IC50: 134.9 mM Alitta virens Phe-Gly