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Literature summary extracted from

  • Rozi, A.; Jia, Y.
    A theoretical study of effects of cytosolic Ca2+ oscillations on activation of glycogen phosphorylase (2003), Biophys. Chem., 106, 193-202.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+ Ca2+-sensitivity of the enzyme is mediated by the delta-subunit which is identical with calmodulin Homo sapiens
3.1.3.17 Ca2+ oscillation of cytosolic Ca2+, has an important regulatory function in the phosphorylation-dephosphorylation cycle for regulation of glycogen phosphorylase activity, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase b Homo sapiens activation of glycogen phosphorylase which acts as a Ca2+-dependent blood glucose sensor liberating glucose from glycogen as needed, involved in regulation of the glycogen phosphorylase ADP + glycogen phosphorylase a
-
 ?
2.7.11.19 additional information Homo sapiens modeling of glycogen phosphorylase regulation by Ca2+-oscillations, and dephosphorylation and phosphorylation involving the enzyme and a phosphatase, overview ?
-
 ?
3.1.3.17 glycogen phosphorylase a + H2O Homo sapiens inactivation of the substrate enzyme as part of the phosphorylation-dephosphorylation cycle for regulation of glycogen phosphorylase activity glycogen phosphorylase b + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Homo sapiens
-
-
-
3.1.3.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.19 hepatocyte
-
 Homo sapiens
-
2.7.11.19 liver
-
 Homo sapiens
-
3.1.3.17 hepatocyte
-
 Homo sapiens
-
3.1.3.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase b
-
 Homo sapiens ADP + glycogen phosphorylase a
-
 ?
2.7.11.19 ATP + glycogen phosphorylase b activation of glycogen phosphorylase which acts as a Ca2+-dependent blood glucose sensor liberating glucose from glycogen as needed, involved in regulation of the glycogen phosphorylase Homo sapiens ADP + glycogen phosphorylase a
-
 ?
2.7.11.19 additional information modeling of glycogen phosphorylase regulation by Ca2+-oscillations, and dephosphorylation and phosphorylation involving the enzyme and a phosphatase, overview Homo sapiens ?
-
 ?
3.1.3.17 glycogen phosphorylase a + H2O
-
 Homo sapiens glycogen phosphorylase b + phosphate
-
 ?
3.1.3.17 glycogen phosphorylase a + H2O inactivation of the substrate enzyme as part of the phosphorylation-dephosphorylation cycle for regulation of glycogen phosphorylase activity Homo sapiens glycogen phosphorylase b + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 hexadecamer alpha4beta4gamma4delta4 Homo sapiens
2.7.11.19 More the delta subunit is identical with calmodulin Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.17 phosphorylase phosphatase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.19 ATP
-
 Homo sapiens
2.7.11.19 Calmodulin mediates Ca2+-sensitivity of the enzyme, calmodulin is identical with the delta-subunit Homo sapiens